THROMBOSIS AND HEMOSTASIS Fibrinogen –derived B 15-42 peptide protects against kidney ischemia/ reperfusion injury
نویسندگان
چکیده
1Renal Division, Department of Medicine, Brigham and Women’s Hospital and 2Center for Biomedical Informatics, Harvard Medical School, Boston, MA; 3Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zúbiran, Mexico City, Mexico; 4Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico; and 5Department of Environmental Health, Harvard School of Public Health, Boston, MA
منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury
Ischemia/reperfusion (IR) injury is a leading cause of acute renal failure and an important contributor to allograft damage. Tissue factor (TF) is up-regulated during IR, and TF inhibition reduces renal injury. However, the underlying mechanisms by which TF contributes to injury have not been elucidated. We postulated that TF contributes to IR injury by production of coagulation proteases and s...
متن کاملFormyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease.
BACKGROUND Platelet activation at sites of vascular injury is essential for hemostasis, but it is also a major pathomechanism underlying ischemic injury. Because anti-inflammatory therapies limit thrombosis and antithrombotic therapies reduce vascular inflammation, we tested the therapeutic potential of 2 proresolving endogenous mediators, annexin A1 N-terminal derived peptide (AnxA1Ac2-26) and...
متن کاملProphylactic Fibrinogen Decreases Postoperative Bleeding but Not Acute Kidney Injury in Patients Undergoing Heart Transplantation.
The present study is the premier clinical attempt to scrutinize the practicability of prophylactic fibrinogen infusion in patients undergoing heart transplantation (HT). A total of 67 consecutive patients who had undergone HT between January 2012 and December 2014 were assessed. After exclusion of some patients, 23 patients were given preoperative 2 g fibrinogen concentrate over a period of 15 ...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Adhesion of human platelets to serum amyloid A
Serum amyloid A (SAA) is an acute phase reactant, and its level in the blood is elevated to 1000-fold in response of the body to trauma, infection, inflammation, and neoplasia. SAA was reported to inhibit platelet aggregation and to induce adhesion of leukocytes. This study looked at adhesion of human platelets to SAA. Immobilized SAA supported the adhesion of human washed platelets; level of a...
متن کاملAntithrombin reduces ischemia/reperfusion-induced renal injury in rats
http://bloodjournal.hematologylibrary.org/content/101/8/3029.full.html Updated information and services can be found at: (973 articles) Phagocytes (2497 articles) Hemostasis, Thrombosis, and Vascular Biology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducin...
متن کامل